Written by Kim Gurwitz     April 08, 2016    
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H3Africa Topics (Categories)
Bioinformatics Topics (EDAM Ontology)
In determining differences between two or more biological conditions, LEfSe "emphasizes both statistical significance and biological relevance, allowing researchers to identify differentially abundant features that are also consistent with biologically meaningful categories (subclasses). LEfSe first robustly identifies features that are statistically different among biological classes. It then performs additional tests to assess whether these differences are consistent with respect to expected biological behavior." - from the website

"LDA Effect Size (LEfSe) (Segata et. al 2010) is an algorithm for high-dimensional biomarker discovery and explanation that identifies genomic features (genes, pathways, or taxa) characterizing the differences between two or more biological conditions" - from the website.
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